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Ca(2+)-dependent Inactivation of Ca(V)1.2 Channels Prevents Gd(3+) Block: Does Ca(2+) Block the Pore of Inactivated Channels?
Lanthanide gadolinium (Gd(3+)) blocks Ca(V)1.2 channels at the selectivity filter. Here we investigated whether Gd(3+) block interferes with Ca(2+)-dependent inactivation, which requires Ca(2+) entry through the same site. Using brief pulses to 200 mV that relieve Gd(3+) block but not inactivation,...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151623/ https://www.ncbi.nlm.nih.gov/pubmed/17535960 http://dx.doi.org/10.1085/jgp.200709734 |