The Role of the Cytoplasmic Pore in Inward Rectification of Kir2.1 Channels

Steeply voltage-dependent block by intracellular polyamines underlies the strong inward rectification properties of Kir2.1 and other Kir channels. Mutagenesis studies have identified several negatively charged pore-lining residues (D172, E224, and E299, in Kir2.1) in the inner cavity and cytoplasmic...

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Detalles Bibliográficos
Autores principales: Kurata, Harley T., Cheng, Wayland W., Arrabit, Christine, Slesinger, Paul A., Nichols, Colin G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151631/
https://www.ncbi.nlm.nih.gov/pubmed/17635958
http://dx.doi.org/10.1085/jgp.200709742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151631/
https://www.ncbi.nlm.nih.gov/pubmed/17635958
http://dx.doi.org/10.1085/jgp.200709742

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