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The Role of a Conserved Lysine in Chloride- and Voltage-dependent ClC-0 Fast Gating
ClC-0 is a chloride channel whose gating is sensitive to voltage, chloride, and pH. In a previous publication, we showed that the K149C mutation causes a +70-mV shift in the voltage dependence of ClC-0 fast gating. In this paper we analyze the effects of a series of mutations at K149 on the voltage...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151651/ https://www.ncbi.nlm.nih.gov/pubmed/17846165 http://dx.doi.org/10.1085/jgp.200709760 |