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Growth arrest-specific protein 6 plasma concentrations during septic shock
INTRODUCTION: The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentra...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151874/ https://www.ncbi.nlm.nih.gov/pubmed/17241453 http://dx.doi.org/10.1186/cc5158 |
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author | Gibot, Sébastien Massin, Frédéric Cravoisy, Aurélie Dupays, Rachel Barraud, Damien Nace, Lionel Bollaert, Pierre-Edouard |
author_facet | Gibot, Sébastien Massin, Frédéric Cravoisy, Aurélie Dupays, Rachel Barraud, Damien Nace, Lionel Bollaert, Pierre-Edouard |
author_sort | Gibot, Sébastien |
collection | PubMed |
description | INTRODUCTION: The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. METHODS: Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1, 3, 7 and 14. RESULTS: The median (interquartile range) Gas6 concentration was 51 (5 to 95) pg/ml at admission. A positive correlation (Spearman rank-order coefficient [rs] = 0.37, P = 0.01) was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher Gas6 concentration that those without need for haemofiltration (76.5 [52 to 164] pg/ml versus 10.5 [1.5 to 80.5] pg/ml; P = 0.04). Moreover, there was a positive correlation between Gas6 and aspartate transaminase (rs = 0.42, P = 0.006) and between Gas6 and prothrombin time (rs = 0.45, P = 0.02). Although there was a progressive decline in Gas6 concentration in survivors (analysis of variance, P = 0.01), nonsurvivors exhibited persistently elevated Gas6. However, the two populations diverged only after day 7 (P = 0.04). CONCLUSION: Plasma concentrations of Gas6 correlate with disease severity, especially with renal and hepatic dysfunction, in septic shock. |
format | Text |
id | pubmed-2151874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-21518742007-12-25 Growth arrest-specific protein 6 plasma concentrations during septic shock Gibot, Sébastien Massin, Frédéric Cravoisy, Aurélie Dupays, Rachel Barraud, Damien Nace, Lionel Bollaert, Pierre-Edouard Crit Care Research INTRODUCTION: The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. METHODS: Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1, 3, 7 and 14. RESULTS: The median (interquartile range) Gas6 concentration was 51 (5 to 95) pg/ml at admission. A positive correlation (Spearman rank-order coefficient [rs] = 0.37, P = 0.01) was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher Gas6 concentration that those without need for haemofiltration (76.5 [52 to 164] pg/ml versus 10.5 [1.5 to 80.5] pg/ml; P = 0.04). Moreover, there was a positive correlation between Gas6 and aspartate transaminase (rs = 0.42, P = 0.006) and between Gas6 and prothrombin time (rs = 0.45, P = 0.02). Although there was a progressive decline in Gas6 concentration in survivors (analysis of variance, P = 0.01), nonsurvivors exhibited persistently elevated Gas6. However, the two populations diverged only after day 7 (P = 0.04). CONCLUSION: Plasma concentrations of Gas6 correlate with disease severity, especially with renal and hepatic dysfunction, in septic shock. BioMed Central 2007 2007-01-22 /pmc/articles/PMC2151874/ /pubmed/17241453 http://dx.doi.org/10.1186/cc5158 Text en Copyright © 2007 Gibot et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Gibot, Sébastien Massin, Frédéric Cravoisy, Aurélie Dupays, Rachel Barraud, Damien Nace, Lionel Bollaert, Pierre-Edouard Growth arrest-specific protein 6 plasma concentrations during septic shock |
title | Growth arrest-specific protein 6 plasma concentrations during septic shock |
title_full | Growth arrest-specific protein 6 plasma concentrations during septic shock |
title_fullStr | Growth arrest-specific protein 6 plasma concentrations during septic shock |
title_full_unstemmed | Growth arrest-specific protein 6 plasma concentrations during septic shock |
title_short | Growth arrest-specific protein 6 plasma concentrations during septic shock |
title_sort | growth arrest-specific protein 6 plasma concentrations during septic shock |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151874/ https://www.ncbi.nlm.nih.gov/pubmed/17241453 http://dx.doi.org/10.1186/cc5158 |
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