Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels

The hyperpolarization-activated cyclic nucleotide-modulated cation (HCN) channels are regulated by both membrane voltage and the binding of cyclic nucleotides to a cytoplasmic, C-terminal cyclic nucleotide-binding domain (CNBD). Here we have addressed the mechanism of this dual regulation for HCN2 c...

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Detalles Bibliográficos
Autores principales: Chen, Shan, Wang, Jing, Zhou, Lei, George, Meena S., Siegelbaum, Steven A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154356/
https://www.ncbi.nlm.nih.gov/pubmed/17261842
http://dx.doi.org/10.1085/jgp.200609585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154356/
https://www.ncbi.nlm.nih.gov/pubmed/17261842
http://dx.doi.org/10.1085/jgp.200609585

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