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Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α
TRIM5α is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5α-mediated MLV restriction. Our results reveal that changes at tyrosine(336) of human TR...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156100/ https://www.ncbi.nlm.nih.gov/pubmed/18166079 http://dx.doi.org/10.1371/journal.ppat.0030200 |