Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

Before a class II molecule can be loaded with antigenic material and reach the surface to engage CD4+ T cells, its chaperone, the class II-associated invariant chain (Ii), is degraded in a stepwise fashion by proteases in endocytic compartments. We have dissected the role of cathepsin S (CatS) in th...

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Detalles Bibliográficos
Autores principales: Driessen, Christoph, Bryant, Rebecca A.R., Lennon-Duménil, Ana-Maria, Villadangos, José A., Bryant, Paula Wolf, Shi, Guo-Ping, Chapman, Harold A., Ploegh, Hidde L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156161/
https://www.ncbi.nlm.nih.gov/pubmed/10562280

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