Presenilin 1 Suppresses the Function of C-Jun Homodimers via Interaction with Qm/Jif-1

Presenilin 1 (PS1) is the causative gene for an autosomal dominant familial Alzheimer's disease (AD) mapped to chromosome 14. Here we show that QM/Jun-interacting factor (Jif)-1, a negative regulator of c-Jun, is a candidate to mediate the function of PS1 in the cell. We screened for proteins t...

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Detalles Bibliográficos
Autores principales: Imafuku, I., Masaki, T., Waragai, M., Takeuchi, S., Kawabata, M., Hirai, S.-i., Ohno, S., Nee, L.E., Lippa, C.F., Kanazawa, I., Imagawa, M., Okazawa, H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164975/
https://www.ncbi.nlm.nih.gov/pubmed/10508860

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