Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest

Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is...

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Detalles Bibliográficos
Autores principales: Fan, Hongran, Khavari, Paul A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164980/
https://www.ncbi.nlm.nih.gov/pubmed/10508856
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author Fan, Hongran
Khavari, Paul A.
author_facet Fan, Hongran
Khavari, Paul A.
author_sort Fan, Hongran
collection PubMed
description Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo. Shh-expressing cells fail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhaustion of replicative growth capacity. In addition, Shh blocks p21(CIP1/WAF1)-induced growth arrest. These data indicate that Shh promotes neoplasia by opposing normal stimuli for epithelial cell cycle arrest.
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spelling pubmed-21649802008-05-01 Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest Fan, Hongran Khavari, Paul A. J Cell Biol Original Article Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo. Shh-expressing cells fail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhaustion of replicative growth capacity. In addition, Shh blocks p21(CIP1/WAF1)-induced growth arrest. These data indicate that Shh promotes neoplasia by opposing normal stimuli for epithelial cell cycle arrest. The Rockefeller University Press 1999-10-04 /pmc/articles/PMC2164980/ /pubmed/10508856 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Fan, Hongran
Khavari, Paul A.
Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title_full Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title_fullStr Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title_full_unstemmed Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title_short Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
title_sort sonic hedgehog opposes epithelial cell cycle arrest
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164980/
https://www.ncbi.nlm.nih.gov/pubmed/10508856
work_keys_str_mv AT fanhongran sonichedgehogopposesepithelialcellcyclearrest
AT khavaripaula sonichedgehogopposesepithelialcellcyclearrest

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