The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate

The human cytomegalovirus protein, US11, initiates the destruction of MHC class I heavy chains by targeting them for dislocation from the ER to the cytosol and subsequent degradation by the proteasome. We report the development of a permeabilized cell system that recapitulates US11-dependent degrada...

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Detalles Bibliográficos
Autores principales: Shamu, Caroline E., Story, Craig M., Rapoport, Tom A., Ploegh, Hidde L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164983/
https://www.ncbi.nlm.nih.gov/pubmed/10508854

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