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Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury
BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the initiation and progression of this disease remain elusive. Previous studies have demonstrated TGFβ1 as a key effector cytokine in t...
Autores principales: | Haider, Yussef, Malizia, Andrea P, Keating, Dominic T, Birch, Mary, Tomlinson, Annette, Martin, Gail, Ferguson, Mark WJ, Doran, Peter P, Egan, Jim J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169220/ https://www.ncbi.nlm.nih.gov/pubmed/17883846 http://dx.doi.org/10.1186/1476-9255-4-18 |
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