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Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia

BACKGROUND: It has been proposed that different types of psychopathology in schizophrenia may reflect distinguishable pathological processes. In the current study we aimed to address such associations in the absence of confounders such as medication and disease chronicity by examining specific relat...

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Autores principales: Whalley, Heather C, Gountouna, Viktoria-Eleni, Hall, Jeremy, McIntosh, Andrew, Whyte, Marie-Claire, Simonotto, Enrico, Job, Dominic E, Owens, David GC, Johnstone, Eve C, Lawrie, Stephen M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169235/
https://www.ncbi.nlm.nih.gov/pubmed/17967171
http://dx.doi.org/10.1186/1471-244X-7-61
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author Whalley, Heather C
Gountouna, Viktoria-Eleni
Hall, Jeremy
McIntosh, Andrew
Whyte, Marie-Claire
Simonotto, Enrico
Job, Dominic E
Owens, David GC
Johnstone, Eve C
Lawrie, Stephen M
author_facet Whalley, Heather C
Gountouna, Viktoria-Eleni
Hall, Jeremy
McIntosh, Andrew
Whyte, Marie-Claire
Simonotto, Enrico
Job, Dominic E
Owens, David GC
Johnstone, Eve C
Lawrie, Stephen M
author_sort Whalley, Heather C
collection PubMed
description BACKGROUND: It has been proposed that different types of psychopathology in schizophrenia may reflect distinguishable pathological processes. In the current study we aimed to address such associations in the absence of confounders such as medication and disease chronicity by examining specific relationships between fMRI activation and individual symptom severity scores in un-medicated subjects at high genetic risk of schizophrenia. METHODS: Associations were examined across two functional imaging paradigms: the Hayling sentence completion task, and an encoding/retrieval task, comprising encoding (at word classification) and retrieval (old word/new word judgement). Symptom severity was assessed using the positive and negative syndrome scale (PANSS). Items examined were hallucinations, delusions, and suspiciousness/persecution. RESULTS: Associations were seen in the anterior middle temporal gyrus in relation to hallucination scores during the sentence completion task, and in the medial temporal lobe in association with suspiciousness/persecution scores in the encoding/retrieval task. Cerebellar activation was associated with delusions and suspiciousness/persecution scores across both tasks with differing patterns of laterality. CONCLUSION: These results support a role for the lateral temporal cortex in hallucinations and medial temporal lobe in positive psychotic symptoms. They also highlight the potential role of the cerebellum in the formation of delusions. That the current results are seen in un-medicated high risk subjects indicates these associations are not specific to the established illness and are not related to medication effects.
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spelling pubmed-21692352007-12-29 Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia Whalley, Heather C Gountouna, Viktoria-Eleni Hall, Jeremy McIntosh, Andrew Whyte, Marie-Claire Simonotto, Enrico Job, Dominic E Owens, David GC Johnstone, Eve C Lawrie, Stephen M BMC Psychiatry Research Article BACKGROUND: It has been proposed that different types of psychopathology in schizophrenia may reflect distinguishable pathological processes. In the current study we aimed to address such associations in the absence of confounders such as medication and disease chronicity by examining specific relationships between fMRI activation and individual symptom severity scores in un-medicated subjects at high genetic risk of schizophrenia. METHODS: Associations were examined across two functional imaging paradigms: the Hayling sentence completion task, and an encoding/retrieval task, comprising encoding (at word classification) and retrieval (old word/new word judgement). Symptom severity was assessed using the positive and negative syndrome scale (PANSS). Items examined were hallucinations, delusions, and suspiciousness/persecution. RESULTS: Associations were seen in the anterior middle temporal gyrus in relation to hallucination scores during the sentence completion task, and in the medial temporal lobe in association with suspiciousness/persecution scores in the encoding/retrieval task. Cerebellar activation was associated with delusions and suspiciousness/persecution scores across both tasks with differing patterns of laterality. CONCLUSION: These results support a role for the lateral temporal cortex in hallucinations and medial temporal lobe in positive psychotic symptoms. They also highlight the potential role of the cerebellum in the formation of delusions. That the current results are seen in un-medicated high risk subjects indicates these associations are not specific to the established illness and are not related to medication effects. BioMed Central 2007-10-29 /pmc/articles/PMC2169235/ /pubmed/17967171 http://dx.doi.org/10.1186/1471-244X-7-61 Text en Copyright © 2007 Whalley et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Whalley, Heather C
Gountouna, Viktoria-Eleni
Hall, Jeremy
McIntosh, Andrew
Whyte, Marie-Claire
Simonotto, Enrico
Job, Dominic E
Owens, David GC
Johnstone, Eve C
Lawrie, Stephen M
Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title_full Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title_fullStr Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title_full_unstemmed Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title_short Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
title_sort correlations between fmri activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169235/
https://www.ncbi.nlm.nih.gov/pubmed/17967171
http://dx.doi.org/10.1186/1471-244X-7-61
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