Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior

Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1 induces an epithelial-like morphology with functio...

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Detalles Bibliográficos
Autores principales: Sander, Eva E., ten Klooster, Jean P., van Delft, Sanne, van der Kammen, Rob A., Collard, John G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169355/
https://www.ncbi.nlm.nih.gov/pubmed/10579721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169355/
https://www.ncbi.nlm.nih.gov/pubmed/10579721

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