Cargando…
Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior
Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1 induces an epithelial-like morphology with functio...
Autores principales: | Sander, Eva E., ten Klooster, Jean P., van Delft, Sanne, van der Kammen, Rob A., Collard, John G. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169355/ https://www.ncbi.nlm.nih.gov/pubmed/10579721 |
Ejemplares similares
-
Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition
por: Zondag, Gerben C.M., et al.
Publicado: (2000) -
Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase
por: Sander, Eva E., et al.
Publicado: (1998) -
The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho
por: van Leeuwen, Frank N., et al.
Publicado: (1997) -
Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function
por: Gimond, Clotilde, et al.
Publicado: (1999) -
The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
Publicado: (1995)