Cargando…

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

Globoid cell leukodystrophy (GLD) is characterized histopathologically by apoptosis of oligodendrocytes, progressive demyelination, and the existence of large, multinuclear (globoid) cells derived from perivascular microglia. The glycosphingolipid, psychosine (d-galactosyl-β-1,1′ sphingosine), accum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Im, Dong-Soon, Heise, Christopher E., Nguyen, Tuan, O'Dowd, Brian F., Lynch, Kevin R.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169470/ https://www.ncbi.nlm.nih.gov/pubmed/11309421

Ejemplares similares

Psychosine, Cytokinesis, and Orphan Receptors: Unexpected Connections
por: Mitchison, T.J.
Publicado: (2001)

Inhibition of Cytokinesis by a Lipid Metabolite, Psychosine
por: Kanazawa, Takayuki, et al.
Publicado: (2000)

Psychosine variants as antigens for natural killer T cells
por: Deng, S., et al.
Publicado: (2017)

CULTIVATION EXPERIMENTS ON THE GLOBOID BODIES OF POLIOMYELITIS
por: Smillie, Wilson G.
Publicado: (1918)

THE CULTIVATION AND IMMUNOLOGICAL REACTIONS OF THE GLOBOID BODIES IN POLIOMYELITIS
por: Amoss, Harold L.
Publicado: (1917)

Clinicopathological Features of Globoid Cell Leucodystrophy in Cats
por: Salvadori, C., et al.
Publicado: (2005)

Globoid Cell Leukodystrophy (Krabbe Disease): An Update
por: Maghazachi, Azzam A
Publicado: (2023)

Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease
por: D’Auria, Ludovic, et al.
Publicado: (2017)

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
por: Abdelkarim, Hazem, et al.
Publicado: (2018)

Analysis of age-related changes in psychosine metabolism in the human brain
por: Marshall, Michael S., et al.
Publicado: (2018)

β-Galactosylceramidase in cancer: more than a psychosine scavenger
por: Belleri, Mirella, et al.
Publicado: (2022)

GLOBOID STRUCTURES IN THE CYTOPLASM OF RAPIDLY GROWING HELA CELLS
por: Harford, Carl G., et al.
Publicado: (1956)

Globoids and Phytase: The Mineral Storage and Release System in Seeds
por: Madsen, Claus Krogh, et al.
Publicado: (2020)

Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy
por: Lin, Dar-Shong, et al.
Publicado: (2023)

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes
por: Cheng, An, et al.
Publicado: (2020)

Newborn Screening for Krabbe Disease—Illinois Experience: Role of Psychosine in Diagnosis of the Disease
por: Basheeruddin, Khaja, et al.
Publicado: (2021)

Low Psychosine in Krabbe Disease with Onset in Late Infancy: A Case Report
por: Corre, Camille S., et al.
Publicado: (2021)

Exonic deletions in GALC are frequent in Japanese globoid-cell leukodystrophy patients
por: Irahara-Miyana, Kaori, et al.
Publicado: (2018)

A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
por: Wu, Guode, et al.
Publicado: (2022)

The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease
por: Reiter, Cory R., et al.
Publicado: (2022)

Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death
por: Voccoli, V, et al.
Publicado: (2014)

Bone Marrow Transplantation Alters the Tremor Phenotype in the Murine Model of Globoid-Cell Leukodystrophy
por: Reddy, Adarsh S., et al.
Publicado: (2012)

Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo
por: Clementino, Adryana, et al.
Publicado: (2021)

Central Nervous System Pathology Progresses Independently of KC and CXCR2 in Globoid-Cell Leukodystrophy
por: Reddy, Adarsh S., et al.
Publicado: (2013)

Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy
por: Kuai, Xiao Ling, et al.
Publicado: (2015)

CD8(+) T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy
por: Sutter, Pearl A., et al.
Publicado: (2023)

Novel genetic variant associated with globoid cell leukodystrophy in a family of mixed breed dogs
por: Hammack, Samantha, et al.
Publicado: (2023)

Brain Targeted AAV1-GALC Gene Therapy Reduces Psychosine and Extends Lifespan in a Mouse Model of Krabbe Disease
por: Herdt, Aimee R., et al.
Publicado: (2023)

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy
por: Ungari, Silvia, et al.
Publicado: (2015)

Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow
por: Watanabe, Hiroshi, et al.
Publicado: (2016)

New insights into globoids of protein storage vacuoles in wheat aleurone using synchrotron soft X-ray microscopy
por: Regvar, Marjana, et al.
Publicado: (2011)

Neural Stem Cell Gene Therapy Ameliorates Pathology and Function in a Mouse Model of Globoid Cell Leukodystrophy
por: Neri, Margherita, et al.
Publicado: (2011)

Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy
por: Lattanzi, Annalisa, et al.
Publicado: (2014)

Achieving Congruence among Reference Laboratories for Absolute Abundance Measurement of Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe Disease
por: Herbst, Zackary, et al.
Publicado: (2020)

Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease
por: Lieberman, Richard, et al.
Publicado: (2022)

Identifying altered developmental pathways in human globoid cell leukodystrophy iPSCs-derived NSCs using transcriptome profiling
por: Lv, Yafeng, et al.
Publicado: (2023)

Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes
por: Mangiameli, Elisabeth, et al.
Publicado: (2021)

Trevor Coward: 'I never thought that just by making an ear for someone, it would change the way they are and give them so much more confidence - it's quite incredible really'
por: O’Dowd, Adrian
Publicado: (2020)

Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021
por: O’Dowd, Aidan
Publicado: (2022)

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors
por: George, Susan R., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_chdhea09fujm4m08aq7dq842tv