Cargando…

Broad and Gag-Biased HIV-1 Epitope Repertoires Are Associated with Lower Viral Loads

BACKGROUND: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) responses and the control of HIV-1, and it is unknown whether the size or distrib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rolland, Morgane, Heckerman, David, Deng, Wenjie, Rousseau, Christine M., Coovadia, Hoosen, Bishop, Karen, Goulder, Philip J. R., Walker, Bruce D., Brander, Christian, Mullins, James I.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170517/ https://www.ncbi.nlm.nih.gov/pubmed/18183304 http://dx.doi.org/10.1371/journal.pone.0001424

Ejemplares similares

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics
por: Rolland, Morgane, et al.
Publicado: (2010)

Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences
por: Rolland, Morgane, et al.
Publicado: (2011)

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
por: Carlson, Jonathan M., et al.
Publicado: (2008)

Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy
por: Huang, Xiao-Li, et al.
Publicado: (2010)

S04-06 OA. Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
por: Julg, B, et al.
Publicado: (2009)

Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins
por: Rolland, Morgane, et al.
Publicado: (2007)

HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques
por: Kulkarni, Viraj, et al.
Publicado: (2014)

HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice
por: Kulkarni, Viraj, et al.
Publicado: (2013)

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
por: Goepfert, Paul A., et al.
Publicado: (2008)

Dynamics and frequency of Gag transmitted polymorphisms in Zambia
por: Schaefer, M, et al.
Publicado: (2012)

P09-18. Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
por: Honeyborne, I, et al.
Publicado: (2009)

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+ T cell activation and killing of virus infected cells
por: Kløverpris, HN, et al.
Publicado: (2012)

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control
por: Mothe, Beatriz, et al.
Publicado: (2012)

Broad TCR Repertoire And Diverse Structural Solutions To Recognition Of An Immunodominant CD8 T Cell Epitope
por: Song, InYoung, et al.
Publicado: (2017)

HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression
por: Archary, Derseree, et al.
Publicado: (2010)

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction
por: Silva-Arrieta, Sandra, et al.
Publicado: (2020)

Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection
por: Ramduth, Danni, et al.
Publicado: (2009)

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques
por: Hu, Xintao, et al.
Publicado: (2018)

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
por: Hurtado, Jonathan, et al.
Publicado: (2023)

HIV/AIDS: global trends, global funds and delivery bottlenecks
por: Coovadia, Hoosen M, et al.
Publicado: (2005)

MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load
por: Janes, Holly, et al.
Publicado: (2012)

Computational Design of Epitope-Enriched HIV-1 Gag Antigens with Preserved Structure and Function for Induction of Broad CD8(+) T Cell Responses
por: Asbach, Benedikt, et al.
Publicado: (2018)

HIV-1 Subtype A Gag Variability and Epitope Evolution
por: Abidi, Syed Hani, et al.
Publicado: (2014)

Preferential targeting of co-evolving Gag residues in long-term non progressors
por: Sunshine, J, et al.
Publicado: (2012)

Coping with Viral Diversity in HIV Vaccine Design
por: Nickle, David C, et al.
Publicado: (2007)

P12-09. Immune responses in controlled and uncontrolled HIV infection to a designed HIV immunogen sequence focused on conserved regions of the viral genome
por: Mothe, B, et al.
Publicado: (2009)

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes
por: Nithichanon, Arnone, et al.
Publicado: (2018)

DNA vaccines expressing conserved elements provide potent and broad immune responses
por: Pavlakis, GN, et al.
Publicado: (2012)

Two commentaries on ‘Impact of tuberculosis preventive therapy on tuberculosis and mortality in HIV-infected children’
por: Coovadia, Hoosen, et al.
Publicado: (2009)

P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection
por: Bansal, A, et al.
Publicado: (2009)

P17-14. Fitness-informed HIV-1 Gag-p24 vaccine design
por: Rolland, MM, et al.
Publicado: (2009)

Comparison of Immunogen Designs That Optimize Peptide Coverage: Reply to Fischer et al
por: Nickle, David C, et al.
Publicado: (2008)

Correction: Comparison of Immunogen Designs That Optimize Peptide Coverage: Reply to Fischer et al
por: Nickle, David C, et al.
Publicado: (2008)

Unique CRF01_AE Gag CTL Epitopes Associated with Lower HIV-Viral Load and Delayed Disease Progression in a Cohort of HIV-Infected Thais
por: Mori, Masahiko, et al.
Publicado: (2011)

The presence of prolines in the flanking region of an immunodominant HIV‐2 gag epitope influences the quality and quantity of the epitope generated
por: Jallow, Sabelle, et al.
Publicado: (2015)

Broadening the repertoire of melanoma-associated T-cell epitopes
por: Frøsig, Thomas Mørch, et al.
Publicado: (2015)

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
por: Brumme, Zabrina L., et al.
Publicado: (2009)

New insights into retroviral Gag–Gag and Gag–membrane interactions
por: Maldonado, José O., et al.
Publicado: (2014)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
por: Wright, JK, et al.
Publicado: (2009)

P17-24. Interfering overlapping epitopes contribute to the subdominance of an HLA-A2-restricted HIV Gag-specific epitope
por: Kan-Mitchell, J, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_g4eojkas2quesvvah6530jh0pv