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Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by LIM kinase (LIMK)–1-mediated phosphorylation and is reactivated by cofilin phosphatase Slingshot (SSH)-1L. In this study, we...

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Detalles Bibliográficos
Autores principales:	Nishita, Michiru, Tomizawa, Chinatsu, Yamamoto, Masahiro, Horita, Yuji, Ohashi, Kazumasa, Mizuno, Kensaku
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171197/ https://www.ncbi.nlm.nih.gov/pubmed/16230460 http://dx.doi.org/10.1083/jcb.200504029

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