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Aβ generation in autophagic vacuoles
Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of β-amyloid (Aβ) deposits called senile or neuritic plaques. Aβ is generated by the proteolytic cleavage of Aβ precursor protein (APP) by β and γ-secretases lo...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171221/ https://www.ncbi.nlm.nih.gov/pubmed/16216920 http://dx.doi.org/10.1083/jcb.200508097 |