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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) in the ER, leading to activation of the unfolded protein response (UPR) and C/EBP homologous protein (CHOP)–induced apoptosis. Here w...

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Detalles Bibliográficos
Autores principales:	DeVries-Seimon, Tracie, Li, Yankun, Yao, Pin Mei, Stone, Elizabeth, Wang, Yibin, Davis, Roger J., Flavell, Richard, Tabas, Ira
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171235/ https://www.ncbi.nlm.nih.gov/pubmed/16203857 http://dx.doi.org/10.1083/jcb.200502078

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