Structural properties and neuronal toxicity of amyotrophic lateral sclerosis–associated Cu/Zn superoxide dismutase 1 aggregates

The appearance of protein aggregates is a characteristic of protein misfolding disorders including familial amyotrophic lateral sclerosis, a neurodegenerative disease caused by inherited mutations in Cu/Zn superoxide dismutase 1 (SOD1). Here, we use live cell imaging of neuronal and nonneuronal cell...

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Detalles Bibliográficos
Autores principales: Matsumoto, Gen, Stojanovic, Aleksandar, Holmberg, Carina I., Kim, Soojin, Morimoto, Richard I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171239/
https://www.ncbi.nlm.nih.gov/pubmed/16216923
http://dx.doi.org/10.1083/jcb.200504050

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