Spying on IgE receptor signaling: simply complex, or not?

Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein–protein interactions in living cells durin...

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Detalles Bibliográficos
Autor principal: Toomre, Derek
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171246/
https://www.ncbi.nlm.nih.gov/pubmed/16275748
http://dx.doi.org/10.1083/jcb.200510105
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author Toomre, Derek
author_facet Toomre, Derek
author_sort Toomre, Derek
collection PubMed
description Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein–protein interactions in living cells during signal transduction. CC-FCS data from studies of IgE receptor signaling challenge models of large stable lipid raft signaling domains and reveal a new complexity in the dynamic (re)organization of signaling complexes.
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spelling pubmed-21712462008-03-05 Spying on IgE receptor signaling: simply complex, or not? Toomre, Derek J Cell Biol Reviews Plasma membrane organization and the potential role, or not, of lipid raft microdomains in signal transduction is a controversial topic. Cross-correlation fluorescent correlation spectroscopy (CC-FCS) shows promise as a new approach to rapidly probe protein–protein interactions in living cells during signal transduction. CC-FCS data from studies of IgE receptor signaling challenge models of large stable lipid raft signaling domains and reveal a new complexity in the dynamic (re)organization of signaling complexes. The Rockefeller University Press 2005-11-07 /pmc/articles/PMC2171246/ /pubmed/16275748 http://dx.doi.org/10.1083/jcb.200510105 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Toomre, Derek
Spying on IgE receptor signaling: simply complex, or not?
title Spying on IgE receptor signaling: simply complex, or not?
title_full Spying on IgE receptor signaling: simply complex, or not?
title_fullStr Spying on IgE receptor signaling: simply complex, or not?
title_full_unstemmed Spying on IgE receptor signaling: simply complex, or not?
title_short Spying on IgE receptor signaling: simply complex, or not?
title_sort spying on ige receptor signaling: simply complex, or not?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171246/
https://www.ncbi.nlm.nih.gov/pubmed/16275748
http://dx.doi.org/10.1083/jcb.200510105
work_keys_str_mv AT toomrederek spyingonigereceptorsignalingsimplycomplexornot

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