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The Rac activator Tiam1 is required for α3β1-mediated laminin-5 deposition, cell spreading, and cell migration

The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the mechanisms by which integrins signal toward Rac are poorly understood. We show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-...

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Detalles Bibliográficos
Autores principales:	Hamelers, Irene H.L., Olivo, Cristina, Mertens, Alexander E.E., Pegtel, D. Michiel, van der Kammen, Rob A., Sonnenberg, Arnoud, Collard, John G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171282/ https://www.ncbi.nlm.nih.gov/pubmed/16330714 http://dx.doi.org/10.1083/jcb.200509172

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