α(4)β(1)-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the α(4)-cytoplasmic domain

The capacity of integrins to mediate adhesiveness is modulated by their cytoplasmic associations. In this study, we describe a novel mechanism by which α(4)-integrin adhesiveness is regulated by the cytoskeletal adaptor paxillin. A mutation of the α(4) tail that disrupts paxillin binding, α(4)(Y991A...

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Detalles Bibliográficos
Autores principales: Alon, Ronen, Feigelson, Sara W., Manevich, Eugenia, Rose, David M., Schmitz, Julia, Overby, Darryl R., Winter, Eitan, Grabovsky, Valentin, Shinder, Vera, Matthews, Benjamin D., Sokolovsky-Eisenberg, Maya, Ingber, Donald E., Benoit, Martin, Ginsberg, Mark H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171310/
https://www.ncbi.nlm.nih.gov/pubmed/16365170
http://dx.doi.org/10.1083/jcb.200503155

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