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Mutational analyses reveal a novel function of the nucleotide-binding domain of γ-tubulin in the regulation of basal body biogenesis
We have used in vitro mutagenesis and gene replacement to study the function of the nucleotide-binding domain (NBD) of γ-tubulin in Tetrahymena thermophila. In this study, we show that the NBD has an essential function and that point mutations in two conserved residues lead to over-production and mi...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171320/ https://www.ncbi.nlm.nih.gov/pubmed/16344310 http://dx.doi.org/10.1083/jcb.200508184 |