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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

Huntington disease (HD) is characterized by the preferential loss of striatal medium-sized spiny neurons (MSNs) in the brain. Because MSNs receive abundant glutamatergic input, their vulnerability to excitotoxicity may be largely influenced by the capacity of glial cells to remove extracellular glut...

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Detalles Bibliográficos
Autores principales:	Shin, Ji-Yeon, Fang, Zhi-Hui, Yu, Zhao-Xue, Wang, Chuan-En, Li, Shi-Hua, Li, Xiao-Jiang
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171327/ https://www.ncbi.nlm.nih.gov/pubmed/16365166 http://dx.doi.org/10.1083/jcb.200508072

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