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PTP-1B is an essential positive regulator of platelet integrin signaling

Outside-in integrin αIIbβ3 signaling is required for normal platelet thrombus formation and is triggered by c-Src activation through an unknown mechanism. In this study, we demonstrate an essential role for protein–tyrosine phosphatase (PTP)–1B in this process. In resting platelets, c-Src forms a co...

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Detalles Bibliográficos
Autores principales:	Arias-Salgado, Elena Garcia, Haj, Fawaz, Dubois, Christophe, Moran, Barry, Kasirer-Friede, Ana, Furie, Barbara C., Furie, Bruce, Neel, Benjamin G., Shattil, Sanford J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171339/ https://www.ncbi.nlm.nih.gov/pubmed/16115959 http://dx.doi.org/10.1083/jcb.200503125

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