It's HIP to be a hub: new trends for old-fashioned proteins

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In net...

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Detalles Bibliográficos
Autores principales: Vecchi, Manuela, Di Fiore, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171400/
https://www.ncbi.nlm.nih.gov/pubmed/16009727
http://dx.doi.org/10.1083/jcb.200506039
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author Vecchi, Manuela
Di Fiore, Pier Paolo
author_facet Vecchi, Manuela
Di Fiore, Pier Paolo
author_sort Vecchi, Manuela
collection PubMed
description Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional “territories:” a possibility with important physiological and pathological implications.
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spelling pubmed-21714002008-03-05 It's HIP to be a hub: new trends for old-fashioned proteins Vecchi, Manuela Di Fiore, Pier Paolo J Cell Biol Reviews Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional “territories:” a possibility with important physiological and pathological implications. The Rockefeller University Press 2005-07-18 /pmc/articles/PMC2171400/ /pubmed/16009727 http://dx.doi.org/10.1083/jcb.200506039 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Vecchi, Manuela
Di Fiore, Pier Paolo
It's HIP to be a hub: new trends for old-fashioned proteins
title It's HIP to be a hub: new trends for old-fashioned proteins
title_full It's HIP to be a hub: new trends for old-fashioned proteins
title_fullStr It's HIP to be a hub: new trends for old-fashioned proteins
title_full_unstemmed It's HIP to be a hub: new trends for old-fashioned proteins
title_short It's HIP to be a hub: new trends for old-fashioned proteins
title_sort it's hip to be a hub: new trends for old-fashioned proteins
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171400/
https://www.ncbi.nlm.nih.gov/pubmed/16009727
http://dx.doi.org/10.1083/jcb.200506039
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