The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N signaling during somitogenesis. Understanding how Dll3 functions is complicated by reports that DSL ligands both a...

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Detalles Bibliográficos
Autores principales: Ladi, Ena, Nichols, James T., Ge, Weihong, Miyamoto, Alison, Yao, Christine, Yang, Liang-Tung, Boulter, Jim, Sun, Yi E., Kintner, Chris, Weinmaster, Gerry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171428/
https://www.ncbi.nlm.nih.gov/pubmed/16144902
http://dx.doi.org/10.1083/jcb.200503113

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