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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

Phosphoinositide (PI) 3-kinase is required for most insulin and insulin-like growth factor (IGF) 1–dependent cellular responses. The p85 regulatory subunit of PI 3-kinase is required to mediate the insulin-dependent recruitment of PI 3-kinase to the plasma membrane, yet mice with reduced p85 express...

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Detalles Bibliográficos
Autores principales:	Luo, Ji, Field, Seth J., Lee, Jennifer Y., Engelman, Jeffrey A., Cantley, Lewis C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171479/ https://www.ncbi.nlm.nih.gov/pubmed/16043515 http://dx.doi.org/10.1083/jcb.200503088

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