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The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

The GTPases Rac and Cdc42 play a pivotal role in the establishment of cell polarity by stimulating biogenesis of tight junctions (TJs). In this study, we show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-lymphoma invasion and metastasis) controls the cell polarity of epidermal k...

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Detalles Bibliográficos
Autores principales:	Mertens, Alexander E.E., Rygiel, Tomasz P., Olivo, Cristina, van der Kammen, Rob, Collard, John G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171536/ https://www.ncbi.nlm.nih.gov/pubmed/16186252 http://dx.doi.org/10.1083/jcb.200502129

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