Lithium induces autophagy by inhibiting inositol monophosphatase

Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating autophagy in mammalian cells is to use rapamycin, which inhibits the mammalian target of rapamycin (mTOR), a negative regulator of autophagy....

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Detalles Bibliográficos
Autores principales: Sarkar, Sovan, Floto, R. Andres, Berger, Zdenek, Imarisio, Sara, Cordenier, Axelle, Pasco, Matthieu, Cook, Lynnette J., Rubinsztein, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171537/
https://www.ncbi.nlm.nih.gov/pubmed/16186256
http://dx.doi.org/10.1083/jcb.200504035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171537/
https://www.ncbi.nlm.nih.gov/pubmed/16186256
http://dx.doi.org/10.1083/jcb.200504035

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