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Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration

Membrane blebbing during the apoptotic execution phase results from caspase-mediated cleavage and activation of ROCK I. Here, we show that ROCK activity, myosin light chain (MLC) phosphorylation, MLC ATPase activity, and an intact actin cytoskeleton, but not microtubular cytoskeleton, are required f...

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Detalles Bibliográficos
Autores principales:	Croft, Daniel R., Coleman, Mathew L., Li, Shuixing, Robertson, David, Sullivan, Teresa, Stewart, Colin L., Olson, Michael F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171584/ https://www.ncbi.nlm.nih.gov/pubmed/15657395 http://dx.doi.org/10.1083/jcb.200409049

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