Going in GTP cycles in the nucleolus

Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellu...

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Detalles Bibliográficos
Autor principal: Misteli, Tom
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171599/
https://www.ncbi.nlm.nih.gov/pubmed/15657389
http://dx.doi.org/10.1083/jcb.200412038
Descripción
Sumario:Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.

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