Going in GTP cycles in the nucleolus

Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellu...

Descripción completa

Detalles Bibliográficos
Autor principal: Misteli, Tom
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171599/
https://www.ncbi.nlm.nih.gov/pubmed/15657389
http://dx.doi.org/10.1083/jcb.200412038
_version_ 1782144951929274368
author Misteli, Tom
author_facet Misteli, Tom
author_sort Misteli, Tom
collection PubMed
description Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.
format Text
id pubmed-2171599
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21715992008-03-05 Going in GTP cycles in the nucleolus Misteli, Tom J Cell Biol Reviews Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting. The Rockefeller University Press 2005-01-17 /pmc/articles/PMC2171599/ /pubmed/15657389 http://dx.doi.org/10.1083/jcb.200412038 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Misteli, Tom
Going in GTP cycles in the nucleolus
title Going in GTP cycles in the nucleolus
title_full Going in GTP cycles in the nucleolus
title_fullStr Going in GTP cycles in the nucleolus
title_full_unstemmed Going in GTP cycles in the nucleolus
title_short Going in GTP cycles in the nucleolus
title_sort going in gtp cycles in the nucleolus
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171599/
https://www.ncbi.nlm.nih.gov/pubmed/15657389
http://dx.doi.org/10.1083/jcb.200412038
work_keys_str_mv AT mistelitom goingingtpcyclesinthenucleolus

Ejemplares similares