Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

We recently reported that uPARAP/Endo180 can mediate the cellular uptake and lysosomal degradation of collagen by cultured fibroblasts. Here, we show that uPARAP/Endo180 has a key role in the degradation of collagen during mammary carcinoma progression. In the normal murine mammary gland, uPARAP/End...

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Detalles Bibliográficos
Autores principales: Curino, Alejandro C., Engelholm, Lars H., Yamada, Susan S., Holmbeck, Kenn, Lund, Leif R., Molinolo, Alfredo A., Behrendt, Niels, Nielsen, Boye Schnack, Bugge, Thomas H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171632/
https://www.ncbi.nlm.nih.gov/pubmed/15967816
http://dx.doi.org/10.1083/jcb.200411153

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