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RPTPα is essential for NCAM-mediated p59(fyn) activation and neurite elongation
The neural cell adhesion molecule (NCAM) forms a complex with p59(fyn) kinase and activates it via a mechanism that has remained unknown. We show that the NCAM140 isoform directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase RPTPα, a known activator of p5...
Autores principales: | Bodrikov, Vsevolod, Leshchyns'ka, Iryna, Sytnyk, Vladimir, Overvoorde, John, den Hertog, Jeroen, Schachner, Melitta |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171675/ https://www.ncbi.nlm.nih.gov/pubmed/15623578 http://dx.doi.org/10.1083/jcb.200405073 |
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