Cargando…

Structurally and functionally unique complexins at retinal ribbon synapses

Ribbon synapses in retinal sensory neurons maintain large pools of readily releasable synaptic vesicles. This allows them to release several hundreds of vesicles per second at every presynaptic release site. The molecular components that cause this high transmitter release efficiency of ribbon synap...

Descripción completa

Detalles Bibliográficos
Autores principales: Reim, Kerstin, Wegmeyer, Heike, Brandstätter, Johann Helmut, Xue, Mingshan, Rosenmund, Christian, Dresbach, Thomas, Hofmann, Kay, Brose, Nils
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171701/
https://www.ncbi.nlm.nih.gov/pubmed/15911881
http://dx.doi.org/10.1083/jcb.200502115
_version_ 1782144963698491392
author Reim, Kerstin
Wegmeyer, Heike
Brandstätter, Johann Helmut
Xue, Mingshan
Rosenmund, Christian
Dresbach, Thomas
Hofmann, Kay
Brose, Nils
author_facet Reim, Kerstin
Wegmeyer, Heike
Brandstätter, Johann Helmut
Xue, Mingshan
Rosenmund, Christian
Dresbach, Thomas
Hofmann, Kay
Brose, Nils
author_sort Reim, Kerstin
collection PubMed
description Ribbon synapses in retinal sensory neurons maintain large pools of readily releasable synaptic vesicles. This allows them to release several hundreds of vesicles per second at every presynaptic release site. The molecular components that cause this high transmitter release efficiency of ribbon synapses are unknown. In the present study, we identified and characterized two novel vertebrate complexins (CPXs), CPXs III and IV, that are the only CPX isoforms present in retinal ribbon synapses. CPXs III and IV are COOH-terminally farnesylated, and, like CPXs I and II, bind to SNAP receptor complexes. CPXs III and IV can functionally replace CPXs I and II, and their COOH-terminal farnesylation regulates their synaptic targeting and modulatory function in transmitter release. The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons.
format Text
id pubmed-2171701
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21717012008-03-05 Structurally and functionally unique complexins at retinal ribbon synapses Reim, Kerstin Wegmeyer, Heike Brandstätter, Johann Helmut Xue, Mingshan Rosenmund, Christian Dresbach, Thomas Hofmann, Kay Brose, Nils J Cell Biol Research Articles Ribbon synapses in retinal sensory neurons maintain large pools of readily releasable synaptic vesicles. This allows them to release several hundreds of vesicles per second at every presynaptic release site. The molecular components that cause this high transmitter release efficiency of ribbon synapses are unknown. In the present study, we identified and characterized two novel vertebrate complexins (CPXs), CPXs III and IV, that are the only CPX isoforms present in retinal ribbon synapses. CPXs III and IV are COOH-terminally farnesylated, and, like CPXs I and II, bind to SNAP receptor complexes. CPXs III and IV can functionally replace CPXs I and II, and their COOH-terminal farnesylation regulates their synaptic targeting and modulatory function in transmitter release. The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons. The Rockefeller University Press 2005-05-23 /pmc/articles/PMC2171701/ /pubmed/15911881 http://dx.doi.org/10.1083/jcb.200502115 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Reim, Kerstin
Wegmeyer, Heike
Brandstätter, Johann Helmut
Xue, Mingshan
Rosenmund, Christian
Dresbach, Thomas
Hofmann, Kay
Brose, Nils
Structurally and functionally unique complexins at retinal ribbon synapses
title Structurally and functionally unique complexins at retinal ribbon synapses
title_full Structurally and functionally unique complexins at retinal ribbon synapses
title_fullStr Structurally and functionally unique complexins at retinal ribbon synapses
title_full_unstemmed Structurally and functionally unique complexins at retinal ribbon synapses
title_short Structurally and functionally unique complexins at retinal ribbon synapses
title_sort structurally and functionally unique complexins at retinal ribbon synapses
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171701/
https://www.ncbi.nlm.nih.gov/pubmed/15911881
http://dx.doi.org/10.1083/jcb.200502115
work_keys_str_mv AT reimkerstin structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT wegmeyerheike structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT brandstatterjohannhelmut structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT xuemingshan structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT rosenmundchristian structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT dresbachthomas structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT hofmannkay structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses
AT brosenils structurallyandfunctionallyuniquecomplexinsatretinalribbonsynapses