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The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum
The Sec61 translocon of the endoplasmic reticulum membrane forms an aqueous pore that is gated by the lumenal Hsp70 chaperone BiP. We have explored the molecular mechanisms governing BiP-mediated gating activity, including the coupling between gating and the BiP ATPase cycle, and the involvement of...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171714/ https://www.ncbi.nlm.nih.gov/pubmed/15684029 http://dx.doi.org/10.1083/jcb.200409174 |