Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53

E2F/DP complexes were originally identified as potent transcriptional activators required for cell proliferation. However, recent studies revised this notion by showing that inactivation of total E2F/DP activity by dominant-negative forms of E2F or DP does not prevent cellular proliferation, but rat...

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Detalles Bibliográficos
Autores principales: Maehara, Kayoko, Yamakoshi, Kimi, Ohtani, Naoko, Kubo, Yoshiaki, Takahashi, Akiko, Arase, Seiji, Jones, Nic, Hara, Eiji
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171766/
https://www.ncbi.nlm.nih.gov/pubmed/15716376
http://dx.doi.org/10.1083/jcb.200411093

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