Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

Activating mutations in fibroblast growth factor receptor 2 (FGFR2) cause several craniosynostosis syndromes by affecting the proliferation and differentiation of osteoblasts, which form the calvarial bones. Osteoblasts respond to FGF with increased proliferation and inhibition of differentiation. W...

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Detalles Bibliográficos
Autores principales: Mansukhani, Alka, Ambrosetti, Davide, Holmes, Greg, Cornivelli, Lizbeth, Basilico, Claudio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171836/
https://www.ncbi.nlm.nih.gov/pubmed/15781477
http://dx.doi.org/10.1083/jcb.200409182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171836/
https://www.ncbi.nlm.nih.gov/pubmed/15781477
http://dx.doi.org/10.1083/jcb.200409182

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