Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently demonstrated that Aβ induced oligodendrocyte (OLG) apoptosis, suggesting a role in white matter pathology in AD. Here, we ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jiunn-Tay, Xu, Jan, Lee, Jin-Moo, Ku, Grace, Han, Xianlin, Yang, Ding-I, Chen, Shawei, Hsu, Chung Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171973/
https://www.ncbi.nlm.nih.gov/pubmed/14709545
http://dx.doi.org/10.1083/jcb.200307017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171973/
https://www.ncbi.nlm.nih.gov/pubmed/14709545
http://dx.doi.org/10.1083/jcb.200307017

Ejemplares similares