Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

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Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunB (Δ/Δ) mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defects before a chronic myeloid leukemia-like disease. Alth...

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Detalles Bibliográficos
Autores principales: Kenner, Lukas, Hoebertz, Astrid, Beil, Timo, Keon, Niamh, Karreth, Florian, Eferl, Robert, Scheuch, Harald, Szremska, Agnieszka, Amling, Michael, Schorpp-Kistner, Marina, Angel, Peter, Wagner, Erwin F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171977/
https://www.ncbi.nlm.nih.gov/pubmed/14769860
http://dx.doi.org/10.1083/jcb.200308155
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