Cargando…

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C–related protein reveals a primordial role in subcellular sphingolipid distribution

Lipid movement between organelles is a critical component of eukaryotic membrane homeostasis. Niemann Pick type C (NP-C) disease is a fatal neurodegenerative disorder typified by lysosomal accumulation of cholesterol and sphingolipids. Expression of yeast NP-C–related gene 1 (NCR1), the orthologue o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malathi, Krishnamurthy, Higaki, Katsumi, Tinkelenberg, Arthur H., Balderes, Dina A., Almanzar-Paramio, Dorca, Wilcox, Lisa J., Erdeniz, Naz, Redican, Francis, Padamsee, Mahajabeen, Liu, Ying, Khan, Sohail, Alcantara, Frederick, Carstea, Eugene D., Morris, Jill A., Sturley, Stephen L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171978/ https://www.ncbi.nlm.nih.gov/pubmed/14970192 http://dx.doi.org/10.1083/jcb.200310046

Ejemplares similares

The expanding boundaries of sphingolipid lysosomal storage diseases; insights from Niemann–Pick disease type C
por: Platt, Frances M.
Publicado: (2023)

Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells
por: Rujoi, Madalina, et al.
Publicado: (2010)

Niemann-Pick Type C Proteins Are Required for Sterol Transport and Appressorium-Mediated Plant Penetration of Colletotrichum orbiculare
por: Kodama, Sayo, et al.
Publicado: (2022)

Inhibition of GM3 Synthase Attenuates Neuropathology of Niemann-Pick Disease Type C by Affecting Sphingolipid Metabolism
por: Lee, Hyun, et al.
Publicado: (2014)

A primordial mover for sphingolipids
por: Dove, Alan W.
Publicado: (2004)

Niemann-Pick disease type C
por: Vanier, Marie T
Publicado: (2010)

Stem Cells and Niemann Pick Disease
por: Andolina, Marino
Publicado: (2014)

Stem Cells in Niemann-Pick Disease
por: Kim, Sun-Jung, et al.
Publicado: (2008)

Niemann-Pick disease and platelet dysfunction
Publicado: (2012)

Picking out primordial seeds
Publicado: (1992)

Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain
por: Dubey, Vikas, et al.
Publicado: (2020)

Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann–Pick C1-Like 1 Protein
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2019)

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
por: Torres, Sandra, et al.
Publicado: (2017)

Niemann-Pick Disease: An Approach for Diagnosis in Adulthood
por: Patiño-Escobar, Bonell, et al.
Publicado: (2019)

Identification and characterization of protein interactions with the major Niemann–Pick type C disease protein in yeast reveals pathways of therapeutic potential
por: Hammond, Natalie, et al.
Publicado: (2023)

Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport
por: Anari, Marziyeh, et al.
Publicado: (2020)

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma
por: Chen, Ke-Ji, et al.
Publicado: (2018)

Clinical disease characteristics of patients with Niemann-Pick Disease Type C: findings from the International Niemann-Pick Disease Registry (INPDR)
por: Bolton, Shaun C., et al.
Publicado: (2022)

Clear Cell Chondrosarcoma in Association With Niemann-Pick Disease
por: Srikanth, K. N., et al.
Publicado: (2005)

Immune dysfunction in Niemann‐Pick disease type C
por: Platt, Nick, et al.
Publicado: (2015)

Anesthetic Management in a Child With Niemann-Pick Disease
por: Espahbodi, Ebrahim, et al.
Publicado: (2016)

Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder
por: Panigrahi, Inusha, et al.
Publicado: (2019)

A calcium message for Niemann-Pick type C
por: Cologna, Stephanie M.
Publicado: (2019)

Treatment trials in Niemann-Pick type C disease
por: Sitarska, Dominika, et al.
Publicado: (2021)

Niemann Pick C disease: lessons from zebrafish development
Publicado: (2011)

Intestinal and Hepatic Niemann-Pick C1-Like 1
por: Park, Sung-Woo
Publicado: (2013)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
por: Lopez, Manuel E, et al.
Publicado: (2012)

Efficacy and ototoxicity of different cyclodextrins in Niemann–Pick C disease
por: Davidson, Cristin D., et al.
Publicado: (2016)

Genome sequencing in a case of Niemann–Pick type C
por: Dougherty, Max, et al.
Publicado: (2016)

Niemann-Pick Diseases: The Largest Iranian Cohort with Genetic Analysis
por: Hashemian, Somayyeh, et al.
Publicado: (2019)

Retinal axonal degeneration in Niemann–Pick type C disease
por: Havla, Joachim, et al.
Publicado: (2020)

Mechanistic convergence and shared therapeutic targets in Niemann‐Pick disease
por: Colaco, Alexandria, et al.
Publicado: (2019)

Estimated prevalence of Niemann–Pick type C disease in Quebec
por: Labrecque, Marjorie, et al.
Publicado: (2021)

Spectrum of Movement Disorders in Niemann-Pick Disease Type C
por: Devaraj, Rashmi, et al.
Publicado: (2022)

Niemann-Pick Disease: A Case Report and Literature Review
por: Vélez Pinos, Paola Jacqueline, et al.
Publicado: (2023)

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
por: Yamada, Yusei, et al.
Publicado: (2023)

Coincidence of Niemann-Pick Disease and beta-Thalassemia; a Case Report
por: Farahmand, Fatemeh, et al.
Publicado: (2010)

Photomyogenic response in Niemann–Pick type C: a case report
por: Bour, A., et al.
Publicado: (2010)

Niemann–Pick disease type C: introduction and main clinical features
por: Burlina, A.
Publicado: (2014)

Genetic and laboratory diagnostic approach in Niemann Pick disease type C
por: McKay Bounford, K., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pm3115gldrtf33h1er9g4nvr8e