Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain

Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP...

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Autores principales: Zippin, Jonathan H., Farrell, Jeanne, Huron, David, Kamenetsky, Margarita, Hess, Kenneth C., Fischman, Donald A., Levin, Lonny R., Buck, Jochen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172001/
https://www.ncbi.nlm.nih.gov/pubmed/14769862
http://dx.doi.org/10.1083/jcb.200311119
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author Zippin, Jonathan H.
Farrell, Jeanne
Huron, David
Kamenetsky, Margarita
Hess, Kenneth C.
Fischman, Donald A.
Levin, Lonny R.
Buck, Jochen
author_facet Zippin, Jonathan H.
Farrell, Jeanne
Huron, David
Kamenetsky, Margarita
Hess, Kenneth C.
Fischman, Donald A.
Levin, Lonny R.
Buck, Jochen
author_sort Zippin, Jonathan H.
collection PubMed
description Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
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spelling pubmed-21720012008-03-05 Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain Zippin, Jonathan H. Farrell, Jeanne Huron, David Kamenetsky, Margarita Hess, Kenneth C. Fischman, Donald A. Levin, Lonny R. Buck, Jochen J Cell Biol Article Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation. The Rockefeller University Press 2004-02-16 /pmc/articles/PMC2172001/ /pubmed/14769862 http://dx.doi.org/10.1083/jcb.200311119 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Zippin, Jonathan H.
Farrell, Jeanne
Huron, David
Kamenetsky, Margarita
Hess, Kenneth C.
Fischman, Donald A.
Levin, Lonny R.
Buck, Jochen
Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title_full Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title_fullStr Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title_full_unstemmed Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title_short Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
title_sort bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear camp microdomain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172001/
https://www.ncbi.nlm.nih.gov/pubmed/14769862
http://dx.doi.org/10.1083/jcb.200311119
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