The mechanism of spindle assembly: functions of Ran and its target TPX2

Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial d...

Descripción completa

Detalles Bibliográficos
Autores principales: Gruss, Oliver J., Vernos, Isabelle
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172015/
https://www.ncbi.nlm.nih.gov/pubmed/15452138
http://dx.doi.org/10.1083/jcb.200312112
_version_ 1782145001058205696
author Gruss, Oliver J.
Vernos, Isabelle
author_facet Gruss, Oliver J.
Vernos, Isabelle
author_sort Gruss, Oliver J.
collection PubMed
description Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle assembly. We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division.
format Text
id pubmed-2172015
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21720152008-03-05 The mechanism of spindle assembly: functions of Ran and its target TPX2 Gruss, Oliver J. Vernos, Isabelle J Cell Biol Reviews Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle assembly. We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division. The Rockefeller University Press 2004-09-27 /pmc/articles/PMC2172015/ /pubmed/15452138 http://dx.doi.org/10.1083/jcb.200312112 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Gruss, Oliver J.
Vernos, Isabelle
The mechanism of spindle assembly: functions of Ran and its target TPX2
title The mechanism of spindle assembly: functions of Ran and its target TPX2
title_full The mechanism of spindle assembly: functions of Ran and its target TPX2
title_fullStr The mechanism of spindle assembly: functions of Ran and its target TPX2
title_full_unstemmed The mechanism of spindle assembly: functions of Ran and its target TPX2
title_short The mechanism of spindle assembly: functions of Ran and its target TPX2
title_sort mechanism of spindle assembly: functions of ran and its target tpx2
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172015/
https://www.ncbi.nlm.nih.gov/pubmed/15452138
http://dx.doi.org/10.1083/jcb.200312112
work_keys_str_mv AT grussoliverj themechanismofspindleassemblyfunctionsofrananditstargettpx2
AT vernosisabelle themechanismofspindleassemblyfunctionsofrananditstargettpx2
AT grussoliverj mechanismofspindleassemblyfunctionsofrananditstargettpx2
AT vernosisabelle mechanismofspindleassemblyfunctionsofrananditstargettpx2

Ejemplares similares