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Conformational control of Bax localization and apoptotic activity by Pro168

In healthy cells, Bax resides inactive in the cytosol because its COOH-terminal transmembrane region (TMB) is tucked into a hydrophobic pocket. During apoptosis, Bax undergoes a conformational change involving NH(2)-terminal exposure and translocates to mitochondria to release apoptogenic factors. H...

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Detalles Bibliográficos
Autores principales:	Schinzel, Anna, Kaufmann, Thomas, Schuler, Martin, Martinalbo, Jorge, Grubb, David, Borner, Christoph
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172067/ https://www.ncbi.nlm.nih.gov/pubmed/15037603 http://dx.doi.org/10.1083/jcb.200309013

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