The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle

The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in ax...

Descripción completa

Detalles Bibliográficos
Autores principales: Korhonen, Laura, Lindholm, Dan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172081/
https://www.ncbi.nlm.nih.gov/pubmed/15067020
http://dx.doi.org/10.1083/jcb.200311091
_version_ 1782145012089225216
author Korhonen, Laura
Lindholm, Dan
author_facet Korhonen, Laura
Lindholm, Dan
author_sort Korhonen, Laura
collection PubMed
description The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders.
format Text
id pubmed-2172081
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21720812008-03-05 The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle Korhonen, Laura Lindholm, Dan J Cell Biol Mini-Review The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders. The Rockefeller University Press 2004-04-12 /pmc/articles/PMC2172081/ /pubmed/15067020 http://dx.doi.org/10.1083/jcb.200311091 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Review
Korhonen, Laura
Lindholm, Dan
The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title_full The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title_fullStr The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title_full_unstemmed The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title_short The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
title_sort ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172081/
https://www.ncbi.nlm.nih.gov/pubmed/15067020
http://dx.doi.org/10.1083/jcb.200311091
work_keys_str_mv AT korhonenlaura theubiquitinproteasomesysteminsynapticandaxonaldegenerationanewtwisttoanoldcycle
AT lindholmdan theubiquitinproteasomesysteminsynapticandaxonaldegenerationanewtwisttoanoldcycle
AT korhonenlaura ubiquitinproteasomesysteminsynapticandaxonaldegenerationanewtwisttoanoldcycle
AT lindholmdan ubiquitinproteasomesysteminsynapticandaxonaldegenerationanewtwisttoanoldcycle

Ejemplares similares