PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

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5-Methylchrysene has been found to be a complete carcinogen in laboratory animals. However, the tumor promotion effects of (±)-anti-5-methylchrysene-1,2-diol-3,4-epoxide (5-MCDE) remain unclear. In the present work, we found that 5-MCDE induced marked activator protein-1 (AP-1) activation in Cl41 ce...

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Detalles Bibliográficos
Autores principales: Li, Jingxia, Chen, Haobin, Tang, Moon-Shong, Shi, Xianglin, Amin, Shantu, Desai, Dhimant, Costa, Max, Huang, Chuanshu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172097/
https://www.ncbi.nlm.nih.gov/pubmed/15067018
http://dx.doi.org/10.1083/jcb.200401004
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