Impacts of a new transcription factor family: mammalian GCM proteins in health and disease

GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashemolhosseini, Said, Wegner, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172107/
https://www.ncbi.nlm.nih.gov/pubmed/15353544
http://dx.doi.org/10.1083/jcb.200406097
_version_ 1782145015597760512
author Hashemolhosseini, Said
Wegner, Michael
author_facet Hashemolhosseini, Said
Wegner, Michael
author_sort Hashemolhosseini, Said
collection PubMed
description GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila melanogaster, whereas mammalian GCM proteins orchestrate divergent aspects of development and physiology in placenta, kidney, thymus, and parathyroid gland. Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors.
format Text
id pubmed-2172107
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21721072008-03-05 Impacts of a new transcription factor family: mammalian GCM proteins in health and disease Hashemolhosseini, Said Wegner, Michael J Cell Biol Reviews GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila melanogaster, whereas mammalian GCM proteins orchestrate divergent aspects of development and physiology in placenta, kidney, thymus, and parathyroid gland. Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors. The Rockefeller University Press 2004-09-13 /pmc/articles/PMC2172107/ /pubmed/15353544 http://dx.doi.org/10.1083/jcb.200406097 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Hashemolhosseini, Said
Wegner, Michael
Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title_full Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title_fullStr Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title_full_unstemmed Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title_short Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
title_sort impacts of a new transcription factor family: mammalian gcm proteins in health and disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172107/
https://www.ncbi.nlm.nih.gov/pubmed/15353544
http://dx.doi.org/10.1083/jcb.200406097
work_keys_str_mv AT hashemolhosseinisaid impactsofanewtranscriptionfactorfamilymammaliangcmproteinsinhealthanddisease
AT wegnermichael impactsofanewtranscriptionfactorfamilymammaliangcmproteinsinhealthanddisease

Ejemplares similares