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Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation

To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation. Myf5-Cre mice, lacking pRb in myoblasts, died immediately at birth and exhibited high numbers of apoptotic nuclei and an almost complete abse...

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Detalles Bibliográficos
Autores principales:	Huh, Michael S., Parker, Maura H., Scimè, Anthony, Parks, Robin, Rudnicki, Michael A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172111/ https://www.ncbi.nlm.nih.gov/pubmed/15364961 http://dx.doi.org/10.1083/jcb.200403004

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